Degrassi

Towers Department Stores were featured in multiple episodes of the Degrassi franchise, specifically in Degrassi Junior High and Degrassi High. According to Degrassi fan sites, the store was used as a filming location, and the distinctive red and white interior helped identify it in the show. The Towers store used in the show is believed to be the one located at 447 Carlaw Avenue in the Riverdale Shopping Centre. 
Towers Department Stores in Degrassi:
Featured in:
Degrassi Junior High and Degrassi High. 
Location:
Likely the Towers store at 447 Carlaw Avenue, Toronto, in the Riverdale Shopping Centre. 
Significance:
The distinctive red and white interior of Towers is noticeable in the show, helping to identify the store. 
Other Details:
A scene in Degrassi High ("What a Night!") specifically features the Towers Department Store at 447 Carlaw Avenue.